Programmable genetic switches to control transcriptional machinery of pluripotency

  title={Programmable genetic switches to control transcriptional machinery of pluripotency},
  author={Ganesh Namasivayam Pandian and Hiroshi Sugiyama},
  journal={Biotechnology Journal},
Transcriptional activators play a central role in the regulation of gene expression and have the ability to manipulate the specification of cell fate. Pluripotency is a transient state where a cell has the potential to develop into more than one type of mature cell. The induction of pluripotency in differentiated cells requires extensive chromatin reorganization regulated by core transcriptional machinery. Several small molecules have been shown to enhance the efficiency of somatic cell… 

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