Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering

@inproceedings{Guha2017ProgrammableGE,
  title={Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering},
  author={Tuhin Kumar Guha and Alvan Wai and G. A. Hedlund Hausner},
  booktitle={Computational and structural biotechnology journal},
  year={2017}
}
Targeted genome editing has become a powerful genetic tool for studying gene function or for modifying genomes by correcting defective genes or introducing genes. A variety of reagents have been developed in recent years that can generate targeted double-stranded DNA cuts which can be repaired by the error-prone, non-homologous end joining repair system or via the homologous recombination-based double-strand break repair pathway provided a suitable template is available. These genome editing… CONTINUE READING
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Insertion of ribozyme based switches into homing endonuclease genes. In: Reeves A, editor. Methods in molecular biology—in vitro mutagenesis: methods and protocols

  • TK Guha, G. Hausner
  • 2016
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