Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering

  title={Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering},
  author={Tuhin Kumar Guha and Alvan Wai and G. A. Hedlund Hausner},
  booktitle={Computational and structural biotechnology journal},
Targeted genome editing has become a powerful genetic tool for studying gene function or for modifying genomes by correcting defective genes or introducing genes. A variety of reagents have been developed in recent years that can generate targeted double-stranded DNA cuts which can be repaired by the error-prone, non-homologous end joining repair system or via the homologous recombination-based double-strand break repair pathway provided a suitable template is available. These genome editing… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
9 Citations
254 References
Similar Papers


Publications citing this paper.
Showing 1-9 of 9 extracted citations


Publications referenced by this paper.
Showing 1-10 of 254 references

Insertion of ribozyme based switches into homing endonuclease genes. In: Reeves A, editor. Methods in molecular biology—in vitro mutagenesis: methods and protocols

  • TK Guha, G. Hausner
  • 2016
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…