Program through Modulation of the Epithelial Cell Differentiation The Transcription Factor Snail Induces Tumor Cell Invasion


Abberant activation of the process of epithelial-mesenchymal transition in cancer cells is a late event in tumor progression. A key inducer of this transition is the transcription factor Snail, which represses E-cadherin. We report that conditional expression of the human transcriptional repressor Snail in colorectal cancer cells induces an epithelial… (More)


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