Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.

@article{Etienne2002PrognosticVO,
  title={Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.},
  author={M. C. Etienne and Maurice Chazal and Pierre Laurent-Puig and Nicolas Magn{\'e} and Christophe Rosty and J. L. Formento and Mireille Francoual and Patricia Formento and Nicole Ren{\'e}e and Emmanuel Chamorey and Andr{\'e} Bourgeon and J E Seitz and J. -R. Delpero and Christian L{\'e}toublon and Denis Pezet and G{\'e}rard Milano},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2002},
  volume={20 12},
  pages={2832-43}
}
PURPOSE The aim of this multicenter prospective study was to evaluate the role of intratumoral parameters related to fluorouracil (FU) sensitivity in 103 metastatic colorectal cancer patients receiving FU-folinic acid. PATIENTS AND METHODS Liver metastatic biopsy specimens were obtained for all patients and primary tumor biopsy specimens for 54 patients. Thymidylate synthase (TS), folylpolyglutamate synthetase, and dihydropyrimidine dehydrogenase were measured by radioenzymatic assays; TS… CONTINUE READING
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