Prognostic value of the epidermal growth factor receptor (EGRF) and p53 in advanced head and neck squamous cell carcinoma patients treated with induction chemotherapy.

@article{Hitt2005PrognosticVO,
  title={Prognostic value of the epidermal growth factor receptor (EGRF) and p53 in advanced head and neck squamous cell carcinoma patients treated with induction chemotherapy.},
  author={Ricardo Hitt and E Ciruelos and Maria de la Luz Olvera Amador and Amparo Benito and Jos{\'e} Javier S{\'a}nchez and Claudio Ballest{\'i}n and Hern{\'a}n Cort{\'e}s-Fun{\'e}s},
  journal={European journal of cancer},
  year={2005},
  volume={41 3},
  pages={453-60}
}
We measured the expression of the p53 nuclear protein and epidermal growth factor receptor (EGFR) in 46 biopsy samples from patients with advanced head and neck cancer treated with induction combination chemotherapy of 5-fluorouracil, cisplatin, and paclitaxel. Tumour expression of p53 protein was analysed with the monoclonal D07 antibody and EGFR with monoclonal H11 antibody. The overall response, defined as complete (CR) and partial response (PR) rates to treatment, was 88%. p53 positive… CONTINUE READING

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