Prognostic value of the DNMTs mRNA expression and genetic polymorphisms on the clinical outcome in oral cancer patients

@article{Supi2016PrognosticVO,
  title={Prognostic value of the DNMTs mRNA expression and genetic polymorphisms on the clinical outcome in oral cancer patients},
  author={Gordana Supi{\'c} and Ru{\vz}ica Kozomara and Katarina Zeljic and Neboj{\vs}a Jovi{\'c} and Zvonko Magi{\'c}},
  journal={Clinical Oral Investigations},
  year={2016},
  volume={21},
  pages={173-182}
}
Although the importance of the epigenetic changes in tumors, including oral squamous cell carcinomas (OSCCs), is now becoming apparent, the mechanisms that trigger or cause aberrant DNA methylation in cancer are still unrevealed. DNA methylation is regulated by a family of enzymes, DNA methyltransferases (DNMTs). DNMT gene expression analysis, as well as genetic polymorphisms, has not been previously evaluated in OSCC. In 65 OSCC patients, SYBR Green real-time PCR method was assessed for… CONTINUE READING

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Although the importance of the epigenetic changes in tumors , including oral squamous cell carcinomas ( OSCCs ) , is now becoming apparent , the mechanisms that trigger or cause aberrant DNA methylation in cancer are still unrevealed . DNA methylation is regulated by a family of enzymes , DNA methyltransferases ( DNMTs ) .
Although the importance of the epigenetic changes in tumors , including oral squamous cell carcinomas ( OSCCs ) , is now becoming apparent , the mechanisms that trigger or cause aberrant DNA methylation in cancer are still unrevealed . DNA methylation is regulated by a family of enzymes , DNA methyltransferases ( DNMTs ) .
Polymorphisms in DNMT1 ( rs2228612 ) and DNMT3B ( rs406193 ) were analyzed in 99 OSCCs by TaqMan SNPs genotyping assays .
Polymorphisms in DNMT1 ( rs2228612 ) and DNMT3B ( rs406193 ) were analyzed in 99 OSCCs by TaqMan SNPs genotyping assays .
Polymorphisms in DNMT1 ( rs2228612 ) and DNMT3B ( rs406193 ) were analyzed in 99 OSCCs by TaqMan SNPs genotyping assays .
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