Prognostic value of syndecan-1 expression in breast cancer.

  title={Prognostic value of syndecan-1 expression in breast cancer.},
  author={Marja Kaarina Leivonen and Johan Lundin and Stig Nordling and Kristina von Boguslawski and Caj Haglund},
  volume={67 1},
OBJECTIVE Syndecan-1 is a cell surface heparan sulphate proteoglycan which participates in cell proliferation, cell migration and cell-matrix interactions. Epithelial syndecan-1 expression is reduced in several malignant tumours, but in breast and pancreatic cancer, increased expression has also been described. Loss of epithelial syndecan-1 has been associated with poor prognosis in some forms of cancer, but previous findings in breast cancer have been contradictory. The objective of this study… CONTINUE READING