Prognostic value of somatostatin receptor subtype 2 expression in colorectal cancer.


The clinical relevance of the somatostatin receptor subtype 2 (sst2) is well defined in neuroendocrine tumors but it is still a matter of debate whether its expression may have a role also in other tumors not arising from the neuroectoderm. We investigated the prognostic value of the expression levels of sst2 mRNA in a consistent group of patients affected by colorectal cancer. Survival analysis of cancer-related death showed that patients with a high sst2 mRNA expression had an unfavourable outcome (p=0.037) and a significantly shorter disease-free survival (p=0.008). Surprisingly, our findings suggest that sst2 gene overexpression is a feature of colorectal tumors that have a negative outlook; in addition, it may allow additional insight into conventional therapeutic approaches for more aggressive tumors, whose prognosis needs to be improved.


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@article{Raggi2005PrognosticVO, title={Prognostic value of somatostatin receptor subtype 2 expression in colorectal cancer.}, author={Claudia Casini Raggi and F. Cianchi and Rosa Valanzano and Michela Cameron Smith and Mario Serio and Mario Maggi and Claudio Orlando}, journal={Regulatory peptides}, year={2005}, volume={132 1-3}, pages={23-6} }