Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma.

  title={Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma.},
  author={Luci{\"e}nne Speleman and Jeroen D. F. Kerrebijn and Maxime P. Look and Cees A. Meeuwis and John A. Foekens and Els M. J. J. Berns},
  journal={Head & neck},
  volume={29 4},
BACKGROUND Tumor cell biological factors, such as urokinase plasminogen activator (uPA) and its inhibitor plasminogen activator inhibitor-1 (PAI-1), cathepsin D, and c-myc play a role in tumor invasion, metastasis, and proliferation. In this study, the prognostic importance of these factors in patients with primary head and neck squamous cell carcinoma (HNSCC) was evaluated and correlated with clinicopathologic variables. METHODS In 46 paired primary tumors and normal tissues, levels of uPA… CONTINUE READING


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