Prognostic value of plasma markers of immune activation in patients with advanced HIV disease treated by combination antiretroviral therapy.

@article{Savs2001PrognosticVO,
  title={Prognostic value of plasma markers of immune activation in patients with advanced HIV disease treated by combination antiretroviral therapy.},
  author={Marianne Sav{\`e}s and Phillipe Morlat and Genevi{\`e}ve Ch{\^e}ne and Evelyne Peuchant and Isabelle Pellegrin and Fabrice Bonnet and Nicole Bernard and Denis Lacoste and Roger Salamon and Jacques Beylot},
  journal={Clinical immunology},
  year={2001},
  volume={99 3},
  pages={347-52}
}
We assessed the prognostic role of plasma levels of beta2-microglobulin, TNF-alpha, sTNFR-II, and IFN-gamma on the progression to AIDS in patients mostly treated with combination antiretroviral therapies. HIV-1-infected patients with advanced HIV disease (baseline CD4+ cell count between 50 and 250 x 10(6)/L) were included in a prospective cohort followed up for 36 months. In the 113 patients included, 22 first AIDS-defining events were reported. Cumulative probability of AIDS was 12% at M12… CONTINUE READING