Prognostic value of nuclear grading assessed by image cytometry for node negative breast cancer patients.


BACKGROUND Although nuclear grading is a useful prognostic factor for node-negative breast cancer, it is difficult to evaluate objectively. In this study, we show the heterogeneity of the nuclear area (NA), and predictive value of NA evaluated by image cytometry. MATERIALS AND METHODS The NA of over 100 cancer cell nuclei were measured by two types of… (More)