Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation.

@article{Kaddar2009PrognosticVO,
  title={Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation.},
  author={Tagrid Kaddar and Wei Wen Chien and Yves Bertrand and Marie Pierre Pag{\`e}s and Jean Pierre Rouault and Gilles Salles and Martine Ffrench and J. P. Magaud},
  journal={Leukemia research},
  year={2009},
  volume={33 9},
  pages={1217-23}
}
miR-16, a miRNA involved in cell proliferation and apoptosis regulation, may interfere with either oncogenic or tumor-suppressor pathways and is implicated in leukemogenesis. We then explored its expression in 93 childhood acute lymphoblastic leukemia (ALL) cases. A high miR-16 expression was associated with hyperleukocytosis and poor cytogenetic groups. In the whole group and in B-cell ALLs, disease-free survival (DFS) was significantly shorter for miR-16 above quartile 75. In T-cell ALLs, for… CONTINUE READING

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