Prognostic value of intratumoral interferon gamma messenger RNA expression in invasive cervical carcinomas.

@article{Tartour1998PrognosticVO,
  title={Prognostic value of intratumoral interferon gamma messenger RNA expression in invasive cervical carcinomas.},
  author={Eric Tartour and Alain Gey and Xavier Sastre-Garau and I Lombard Surin and Véronique Mosseri and Wolf Herman Fridman},
  journal={Journal of the National Cancer Institute},
  year={1998},
  volume={90 4},
  pages={
          287-94
        }
}
BACKGROUND The production of the cytokine interferon gamma (IFN gamma) by activated peripheral blood mononuclear cells may be reduced in patients with invasive cervical carcinoma. This study was designed to assess the prognostic value of intratumoral IFN gamma messenger RNA (mRNA) levels in such patients. METHODS Biopsy specimens of primary cervical lesions were obtained from 27 patients with invasive squamous cell carcinoma before they received any therapy. Two prognostic groups were… 
Expression and polimorphism of IFN-gamma gene in patients with cervical cancer.
TLDR
This is the first evidence for effecting IFN-gamma gene on the risk of cervical cancer in north Indian population and the sqRT-PCR reflected the similar level of mRNA expression ofIFN- gamma gene in patients suffering from cervical carcinoma and healthy controls.
The prognostic time dependence of intra-tumoural IFNγ mRNA and protein in patients with breast cancer followed for 14 years after surgery and radiotherapy, without subsequent systemic therapy
TLDR
This study contributes to clarification of the previously inconsistent prognostic performance of IFNγ by providing the first prognostic evaluation with long follow-up, time-dependence assessment and absence of any chemotherapy influence.
Cytokine profile of cervical cancer cells.
TLDR
The results suggest that cervical carcinoma cells produce immunomodulatory cytokines and that cytokine expression patterns change after malignant transformation, and the implications of locally produced cytokines by cervical cancer cells are suggested.
The relevance of oncogenes as prognostic markers in cervical cancer
  • L. Soh, D. Heng, I. Lee, T. Ho, K. Hui
  • Medicine, Biology
    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • 2002
TLDR
A correlation appears between the amplification of the oncogenes c-myc, c-erbB2, and H-ras codon 12, 13, and 61 and the development of recurrent cervical cancer.
The relevance of oncogenes as prognostic markers in cervical cancer
TLDR
A correlation appears between the amplification of the oncogenes c-myc, c-erbB2, and H-ras codon 12, 13, and 61 and the development of recurrent cervical cancer.
Cytokine dysregulation in invasive cervical carcinoma and other human neoplasias: time to consider the TH1/TH2 paradigm.
Tumor immunology has evolved in parallel with the immunology of infectious diseases and has attempted to reproduce the successes obtained in the prevention and cure of infections by directing the
Analysis of the expression of HLA class I, proinflammatory cytokines and chemokines in primary tumors from patients with localized and metastatic renal cell carcinoma.
TLDR
It is observed that disease progression and development of metastasis in RCC are associated with decreased expression of HLAhc, beta2m, IP-10, SDF-1 and IFN-gamma, and this microenvironment may suppress the cytotoxic response, creating conditions that favor tumor escape and cancer progression.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 48 REFERENCES
Cytokine production patterns in cervical intraepithelial neoplasia: association with human papillomavirus infection.
TLDR
Production of cytokines that mainly enhance potentially protective cell-mediated immunity is defective in the women in whom extended HPV infection was observed, and a pronounced shift from type 1 to type 2 cytokine production is associated with more extensive HPV infection.
Leukoregulin and gamma-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus-immortalized human cervical cells.
TLDR
This is the first demonstration that LR and r-IFN gamma selectively inhibit transcription of HPV-transforming genes and suggests a molecular mechanism by which these lymphokines participate in regression of premalignant cells.
Altered HLA expression by metastatic cervical carcinoma cells as a factor in impaired immune surveillance.
TLDR
Findings suggest that in cervical carcinoma loss of HLA class I expression plays a decisive role in the escape from immune surveillance leading to a greater metastatic potential of tumor cells.
HLA-DR antigen expression in colorectal carcinomas: influence of expression by IFN-gamma in situ and its association with tumour progression.
TLDR
In vivo observations from the investigation of the host's immune response against colorectal carcinoma through the expression of HLA-DR antigen on carcinoma cells on normal epithelia immediately adjacent to carcinoma (AN) might be clinically applicable to the prediction of patients' immune responsiveness to carcinomas.
Enhanced expression of interleukin-6 in primary human renal cell carcinomas.
TLDR
Evidence is provided that IL-6 and its receptor may play a role in promoting the transformation and/or proliferation of renal cell carcinomas as well as in teh development of symptoms.
Analysis of interleukin 6 gene expression in cervical neoplasia using a quantitative polymerase chain reaction assay: evidence for enhanced interleukin 6 gene expression in invasive carcinoma.
TLDR
It is confirmed, in vivo, that IL-6 may play a role in the pathogenesis of carcinoma of the uterine cervix since its increased expression is associated with advanced neoplastic cervical lesions.
Bladder cancer. Human leukocyte antigen II, interleukin‐6, and interleukin‐6 receptor expression determined by the polymerase chain reaction
TLDR
Although an improved predictive index based on gene expression analysis by RNA/PCR has not been realized, a broader survey of human tumors for expression of these genes and others is likely to refine the classification of bladder cancer.
Expression of mRNA for cytokines in tumor‐infiltrating mononuclear cells in ovarian adenocarcinoma and invasive breast cancer
TLDR
Strong evidence for local activation of mononuclear cells in situ, exemplified by the expression of genes for cytokines, was obtained only in inflammatory lesions and in mucin‐producing breast carcinomas.
...
1
2
3
4
5
...