Prognostic value of chromosome 1q21 gain by fluorescent in situ hybridization and increase CKS1B expression in myeloma

@article{Fonseca2006PrognosticVO,
  title={Prognostic value of chromosome 1q21 gain by fluorescent in situ hybridization and increase CKS1B expression in myeloma},
  author={Rafael Fonseca and S A Van Wier and W J Chng and Rhett P. Ketterling and Martha Q. Lacy and Angela Dispenzieri and Peter Leif Bergsagel and S Vincent Rajkumar and Philip R. Greipp and Mark R Litzow and Tammy L. Price-Troska and Kimberly J Henderson and Greg J. Ahmann and Morie A Gertz},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={2034-2040}
}
A specific role for increased level of expression of CKS1B, as a consequence of chromosome 1q21 copy number gain, has been postulated as both pathogenic, as well as a powerful clinical prognostic factor in multiple myeloma (MM). The purpose of this study is to determine the clinical associations and prognostic impact of copy number gain at chromosome 1q21 (with a bacteria artificial chromosome clone containing CKS1B) and CKS1B gene level of expression in MM. We studied the chromosome region… CONTINUE READING
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