Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma.

@article{Bron2013PrognosticVO,
  title={Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma.},
  author={Luc P Bron and Camilla Jandus and Snezana Andrejevic-Blant and Daniel E Speiser and Philippe M Monnier and Pedro Romero and Jean-Paul Rivals},
  journal={International journal of cancer},
  year={2013},
  volume={132 3},
  pages={
          E85-93
        }
}
Tumor-infiltrating lymphocytes are present in a variety of tumors and play a central role in antitumor immune responses. Nevertheless, most cancers progress probably because tumors are only weakly immunogenic and develop multiple immunosuppressive mechanisms. In the present study, on head and neck squamous cell carcinoma, we found high intraepithelial infiltration of regulatory FOXP3(+) T cells, and relatively high levels of BDCA2(+) and FOXP3(+) cells in stromal (peripheral) regions of the… CONTINUE READING

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