Corpus ID: 10490979

Prognostic value of PD-L 1 expression in non-small cell lung cancer : a meta-analysis

@inproceedings{Fan2017PrognosticVO,
  title={Prognostic value of PD-L 1 expression in non-small cell lung cancer : a meta-analysis},
  author={Y. Fan and K. Ma and Yuan Hu and Wenxia Niu and E. Li and Yinying Wu},
  year={2017}
}
Purpose: We conducted a meta-analysis to systematically assess the prognostic and clinicopathological value of programmed death ligand-1 (PD-L1) expression in non-small cell lung cancer (NSCLC). Methods: We searched PubMed, Embase and Web of Science to screen the literature for relevant studies up date to September 29, 2016. The associations of PD-L1 expression with clinicopathological parameters and overall survival (OS) were investigated using the meta-analysis for odds ratio (OR) or hazard… Expand

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References

SHOWING 1-10 OF 41 REFERENCES
A meta-analysis reveals prognostic role of programmed death ligand-1 in Asian patients with non-small cell lung cancer
  • Xiaoyan Hu, Wei Zhang, +4 authors Li Liu
  • Medicine
  • Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • 2016
TLDR
It is demonstrated that PD-L1 has a prognostic role in Asian patients with NSCLC, and the pooled hazard ratios with 95% confidence intervals for overall survival (OS) and odd ratios (ORs) for clinicopathologic factors were calculated. Expand
The prognostic value of PD-L1 expression for non-small cell lung cancer patients: a meta-analysis.
  • A. Wang, H. Y. Wang, +6 authors G. Liu
  • Medicine
  • European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • 2015
TLDR
A meta-analysis was conducted to investigate the much-debated relationship between the gene expression of programmed cell death-ligand 1 (PD-L1) and cancer patient prognosis and found that NSCLC patients with positive PD-L 1 expression exhibited poor OS. Expand
PD-L1 over-expression and survival in patients with non-small cell lung cancer: a meta-analysis.
TLDR
It is suggested that PD-L1 overexpression had a poor impact on survival of patients with NSCLC, and this meta-analysis indicates a poor prognosis for patients withNSCLC. Expand
Prognostic value of programmed cell death-ligand 1 expression in patients with non-small-cell lung cancer: evidence from an updated meta-analysis
TLDR
A meta-analysis of all available studies to evaluate the prognostic role of PD-L1 expression and prognosis for patients with non-small-cell lung cancer indicated no statistically significant difference. Expand
Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a meta-analysis.
TLDR
A meta-analysis indicated PD-L1 protein expression in NSCLC was not associated with common clinicopathological characteristics, except tumor differentiation, and was a poor prognostic biomarker for NSCLCs. Expand
PD-L1 expression is a favorable prognostic factor in early stage non-small cell carcinoma.
TLDR
PD-L1 is expressed at high levels in a significant proportion of NSCLC and appears to be a favorable prognostic factor in early stage disease, and further studies are recommended. Expand
Programmed death-ligand 1 expression associated with molecular characteristics in surgically resected lung adenocarcinoma
TLDR
PD-L1 overexpression is more frequently observed in oncogene-mediated lung adenocarcinoma, especially with coexisting mutation subtypes, and is not an independent risk factor for poor DFS and overall survival (OS) in surgically resected NSCLC patients. Expand
The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs
TLDR
High PD-L1 expression was likely to be associated with the presence of EGFR mutation in advanced lung adenocarcinoma, and this can be considered as a poor prognostic indicator of OS for EGFR wild-type patients. Expand
Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer.
  • K. Azuma, K. Ota, +10 authors I. Okamoto
  • Medicine
  • Annals of oncology : official journal of the European Society for Medical Oncology
  • 2014
TLDR
High expression of PD-L1 was associated with the presence of EGFR mutations in surgically resected NSCLC and was an independent negative prognostic factor for this disease. Expand
Programmed death ligand-1 expression in non-small cell lung cancer
TLDR
Multivariate analysis showed that PD-L1 expression was significantly associated with better outcome independent of histology and further studies are required to determine the value of this marker in prognosis and prediction of response to treatments targeting this pathway. Expand
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