Prognostic value and clinicopathologic correlation of p53 gene mutations and nuclear DNA content in human lung cancer: a prospective study.

@article{Casson1994PrognosticVA,
  title={Prognostic value and clinicopathologic correlation of p53 gene mutations and nuclear DNA content in human lung cancer: a prospective study.},
  author={Alan G. Casson and Sarah McCuaig and I. R. Craig and Amine Ayed and Richard Inculet and Nancy A. Kerkvliet and F M O'Malley},
  journal={Journal of surgical oncology},
  year={1994},
  volume={56 1},
  pages={
          13-20
        }
}
  • Alan G. Casson, Sarah McCuaig, +4 authors F M O'Malley
  • Published in Journal of surgical oncology 1994
  • Medicine
  • The aim of this prospective study was to determine whether use of a combination of biomarkers, p53 and nuclear DNA content, led to improved prognosis and clinicopathologic correlation in human non-small cell lung cancer. Nineteen patients undergoing curative resection of primary non-small cell lung cancer were evaluated. Resected tumors were studied by polymerase chain reaction/single strand conformation polymorphism analysis (p53 gene mutations), flow cytometry (nuclear DNA content and cell… CONTINUE READING

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