Prognostic significance of tumor-related genes hypermethylation detected in cancer-free surgical margins of oral squamous cell carcinomas.

@article{Supi2011PrognosticSO,
  title={Prognostic significance of tumor-related genes hypermethylation detected in cancer-free surgical margins of oral squamous cell carcinomas.},
  author={Gordana Supi{\'c} and Ru{\vz}ica Kozomara and Neboj{\vs}a Jovi{\'c} and Katarina Zeljic and Zvonko Magi{\'c}},
  journal={Oral oncology},
  year={2011},
  volume={47 8},
  pages={702-8}
}
Oral squamous cell carcinoma (OSCC) is characterized by high mortality rates. High incidence of local recurrences in the normal-appearing surgical margins of OSCC patients indicates the existence molecular alterations, including DNA methylation, which could not be detectable by histopathologic analysis. The objective of our study was to determine correlation of tumor-related genes hypermethylation detected in histopathologically negative surgical margins with clinical and prognostic parameters… CONTINUE READING
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