Prognostic significance of the tumor suppressor gene maspin in non-small cell lung cancer.

  title={Prognostic significance of the tumor suppressor gene maspin in non-small cell lung cancer.},
  author={Kyoji Hirai and Kiyoshi Koizumi and Shuji Haraguchi and Tomomi Hirata and Iwao Mikami and Mitsuhiro Fukushima and Shigeki Yamagishi and Tetsuo Kawashima and Daisuke Okada and Kazuo Shimizu and Masashi Kawamoto},
  journal={The Annals of thoracic surgery},
  volume={79 1},
BACKGROUND Maspin is a serpin protease inhibitor, which is known to suppress tumor progression in breast cancer and to be regulated by wild-type p53. This study was performed to elucidate the biologic significance of maspin expression in non-small cell lung cancer. METHODS To investigate whether maspin is involved in progression, clinicopathologic features, and prognosis of non-small cell lung cancer, we performed an immunohistochemical study using antimaspin antibody and identified the… CONTINUE READING


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