Prognostic significance of reduced expression of beta-N-acetylgalactosaminylated N-linked oligosaccharides in human breast cancer.

@article{Kitamura2003PrognosticSO,
  title={Prognostic significance of reduced expression of beta-N-acetylgalactosaminylated N-linked oligosaccharides in human breast cancer.},
  author={Noriaki Kitamura and Shanchun Guo and Takeshi Sato and Sen Hiraizumi and Junko Taka and Masahiko Ikekita and Shuzo Sawada and Hirosuke Fujisawa and Kiyoshi Furukawa},
  journal={International journal of cancer},
  year={2003},
  volume={105 4},
  pages={533-41}
}
Our previous studies showed that expression of the GalNAcbeta1-->4GlcNAc group on N-linked oligosaccharides is associated with functional differentiation of the bovine mammary gland. In the present study, the occurrence of the GalNAcbeta1-->4GlcNAc group was established in human milk proteins and membrane glycoproteins from a human breast cancer cell line, MRK-nu-1, by structural analysis of oligosaccharides released by hydrazinolysis. Whether the expression level of the disaccharide group is… CONTINUE READING
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