Prognostic significance of promoter DNA methylation in patients with childhood neuroblastoma.

@article{Lau2012PrognosticSO,
  title={Prognostic significance of promoter DNA methylation in patients with childhood neuroblastoma.},
  author={Diana T. Lau and Luke B. Hesson and Murray D. Norris and Glenn M. Marshall and Michelle Haber and Lesley Jayne Ashton},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 20},
  pages={5690-700}
}
PURPOSE To characterize the clinical significance of promoter methylation in a cohort of primary neuroblastoma tumors and investigate the association between DNA methylation and clinical outcome. EXPERIMENTAL DESIGN A customized Illumina GoldenGate methylation assay was used to assess methylation status of 96 CpG sites within 48 candidate genes in primary neuroblastoma tumors obtained from 131 children diagnosed in Australia. Genes were selected on the basis of previous reports of altered DNA… CONTINUE READING
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