Prognostic-significance of p53 mutations in small non-cleaved cell lymphomas.

  title={Prognostic-significance of p53 mutations in small non-cleaved cell lymphomas.},
  author={Manuel S{\'a}nchez Guti{\'e}rrez and Kishor Bhatia and Blanca D. Diez and Federico Sackmann Muriel and Sidnel Epelman and M Deandreas and Konrad E. Huppi and Ian T. Magrath},
  journal={International journal of oncology},
  volume={4 3},
We have assessed the prognostic significance of mutations in the p53 tumor suppressor gene in patients with small non-cleaved cell lymphomas. In this retrospective pilot study we have, been able to evaluate the response to therapy of 21 previously untreated patients. Seven of these patients (33%) had tumors which contained a p53 mutation at presentation. Five of the 7 patients with mutant p53 relapsed and 4 died of progressive disease whereas none of the patients with wild type p53 relapsed and… CONTINUE READING