Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine.

@article{Brueckl2004PrognosticSO,
  title={Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine.},
  author={Wolfgang Michael Brueckl and Elvira Heinze and Catrin Milsmann and Axel Wein and Corinna Koebnick and Andreas Jung and Roland Croner and T. Brabletz and Klaus Guenther and Thomas W. Kirchner and Eckhart Georg Hahn and Werner Hohenberger and Heinz Becker and Bertram Reingruber},
  journal={Cancer letters},
  year={2004},
  volume={203 2},
  pages={181-90}
}
Adenocarcinoma of the small intestine (ACSI) is a rare condition with few studies addressing follow-up and prognosis. Tumors of 35 patients with curative resection of an ACSI were retrospectively analyzed by immunohistochemistry: p53, hMLH1, hMSH2 and hMSH6 and microsatellite instability (MSI): BAT-26, BAX, TGF-beta RII. With a median follow up of 6.1 years, the median cancer-specific survival (CSS) was 36.2 months. Patients who were highly instable (MSI-H) (n=10) had a CSS of 49.6 months in… CONTINUE READING
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