Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation

@article{Holler2000PrognosticSO,
  title={Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation},
  author={Ernst Holler and M G Roncarolo and R Hintermeier-Knabe and G{\"u}nther Eissner and Bernhard Ertl and Ute Schulz and Helmuth Knabe and H. J. Kolb and Reinhard Andreesen and Wolfgang Wilmanns},
  journal={Bone Marrow Transplantation},
  year={2000},
  volume={25},
  pages={237-241}
}
IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine. To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 patients admitted for allogeneic BMT. High spontaneous IL-10 production by PBMNC at the time of… CONTINUE READING

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