Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.

@article{Schwind2010PrognosticSO,
  title={Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.},
  author={Sebastian Schwind and Kati S. Maharry and Michael D. Radmacher and Krzysztof Mr{\'o}zek and Kelsi B Holland and Dean P Margeson and Susan P. Whitman and Christopher Hickey and Heiko Becker and Klaus H Metzeler and Peter Paschka and Claudia Dorothea Baldus and Shujun Liu and Ramiro Garzon and Bayard L. Powell and Jonathan E Kolitz and Andrew J. Carroll and Michael A. Caligiuri and Richard A Larson and Guido Marcucci and Clara D. Bloomfield},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 36},
  pages={5257-64}
}
PURPOSE To evaluate the prognostic significance of expression levels of a single microRNA, miR-181a, in the context of established molecular markers in cytogenetically normal acute myeloid leukemia (CN-AML), and to gain insight into the leukemogenic role of miR-181a. PATIENTS AND METHODS miR-181a expression was measured in pretreatment marrow using Ohio State University Comprehensive Cancer Center version 3.0 arrays in 187 younger (<60 years) adults with CN-AML. Presence of other molecular… CONTINUE READING