Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell carcinoma.

@article{Ranelletti2001PrognosticSO,
  title={Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell carcinoma.},
  author={Franco Oreste Ranelletti and Giovanni Almadori and Barbara Rocca and Gabriella Ferrandina and Giovanni Ciabattoni and Aggad Habib Aggad Habib and Jessica Galli and Nicola Giuseppe Maggiano and Marco Gessi and Libero Lauriola},
  journal={International journal of cancer},
  year={2001},
  volume={95 6},
  pages={
          343-9
        }
}
Epidermal growth factor receptor (EGFR) overexpression is an unfavorable prognostic marker in laryngeal squamous cell carcinoma (SCC). EGFR stimulates cyclooxygenase-2 (COX-2) expression in normal human keratinocytes and squamous carcinoma cells. Based on these observations a prognostic role of COX-2 expression in laryngeal SCC can be hypothesized. Consequently, COX-2 expression was studied in laryngeal SCC (median follow-up = 47 months; range: 2-87 months) by quantitative immunohistochemistry… CONTINUE READING
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