Prognostic significance of cyclin D1 amplification and overexpression in oral squamous cell carcinomas.

@article{Miyamoto2003PrognosticSO,
  title={Prognostic significance of cyclin D1 amplification and overexpression in oral squamous cell carcinomas.},
  author={Ryozo Miyamoto and Narikazu Uzawa and Shunya Nagaoka and Yasushi Hirata and Teruo Amagasa},
  journal={Oral oncology},
  year={2003},
  volume={39 6},
  pages={610-8}
}
Amplification and overexpression of cyclin D1 (CCND1) have been reported as independent prognostic indicators of several tumors. To investigate the association between CCND1 amplification and overexpression in oral squamous cell carcinomas (OSCCs), and to determine which is more reliable as a prognostic indicator, fluorescence in situ hybridization (FISH) on fine-needle aspiration (FNA) biopsies and immunohistochemistry were performed on 41 primary OSCCs (26 males, 15 females; mean age; 58.4… CONTINUE READING

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