Prognostic significance of bone morphogenetic activity in osteosarcoma tissue.

  title={Prognostic significance of bone morphogenetic activity in osteosarcoma tissue.},
  author={Hideki Yoshikawa and Kunio Takaoka and Kensaku Masuhara and Katsuhiro Ono and Yoshihiro Sakamoto},
  volume={61 3},
The bone morphogenetic activities of the primary tumors of 30 patients with osteosarcoma were assayed. This activity was demonstrated as ectopic new bone formation on implantation of freeze-dried fractions of 12 of 30 tumors into athymic nude mice. Pulmonary metastases developed in ten (83%) of the 12 patients with osteosarcomas that produced bone morphogenetic protein (BMP), and bone metastases developed in six (50%) of the patients. The mean period from diagnosis to metastasis was 4.2 months… CONTINUE READING


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