Prognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer.

@article{Evans1993PrognosticSO,
  title={Prognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer.},
  author={Thomas Rj Evans and Martin G. Rowlands and M C Silva and M. Law and R C Coombes},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1993},
  volume={44 4-6},
  pages={583-7}
}
The aromatase and estrone sulfatase enzymes are important sources of local synthesis of biologically active estrogens in human breast cancer. Significant intratumoral aromatase activity was detected in 91/145 (63%) of tumors and estrone sulfatase was detected in 93/104 (89%) of tumors. There was no relationship between aromatase activity and tumor size, site, nodal status, menopausal status or estrogen receptor status. There was a significant correlation between the aromatase activity and… CONTINUE READING

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