Prognostic significance of X-ray cross-complementing group 1 T-77C polymorphism in resected non-small cell lung cancer.

@article{Hsieh2009PrognosticSO,
  title={Prognostic significance of X-ray cross-complementing group 1 T-77C polymorphism in resected non-small cell lung cancer.},
  author={Wei-Chung Hsieh and Ya-Wen Cheng and Cuei-Jyuan Lin and M P Chou and Chih-Yi Chen and Huei Lee},
  journal={Japanese journal of clinical oncology},
  year={2009},
  volume={39 2},
  pages={81-5}
}
OBJECTIVE A novel T-77C polymorphism in the promoter region of the DNA repair gene X-ray cross-complementing group 1 (XRCC1) may modulate its transcription to increase the risk of lung cancer. Here, we attempt to clarify: (i) whether the XRCC1 T-77C polymorphism was associated with lung cancer risk in Taiwanese and (ii) whether this polymorphism could act as a prognostic indicator to predict the clinical outcome of non-small-cell lung cancer (NSCLC) patients. METHODS A total of 294 primary… CONTINUE READING
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