Prognostic significance of CD38 and CD20 expression as assessed by quantitative flow cytometry in chronic lymphocytic leukaemia.

@article{Hsi2003PrognosticSO,
  title={Prognostic significance of CD38 and CD20 expression as assessed by quantitative flow cytometry in chronic lymphocytic leukaemia.},
  author={E D Hsi and Kenneth J. Kopecky and Frederick R Appelbaum and David H. Boldt and T. J. Frey and Margaret Loftus and Mohamed A. Hussein},
  journal={British journal of haematology},
  year={2003},
  volume={120 6},
  pages={1017-25}
}
CD38 expression on chronic lymphocytic leukaemia (CLL) cells is a poor prognostic factor, however, methods for measuring this vary. The QuantiBRITETM flow cytometry (FC) system yields an absolute antigen expression value (antibodies bound/cell, ABC) and may be useful in standardizing CD38 expression analysis. We evaluated cryopreserved pretreatment CLL cells for CD20 ABC, CD38 ABC, and percentage of CD38+ B cells from 131 patients requiring therapy. The 92 patients (70%) with >/= 100 CD38 ABC… CONTINUE READING

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