Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer.

@article{Betticher1996PrognosticSO,
  title={Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer.},
  author={Daniel Charles Betticher and Jim Heighway and Philip S Hasleton and Hans Joerg Altermatt and William J. Ryder and Thomas Cerny and Nicholas Thatcher},
  journal={British Journal of Cancer},
  year={1996},
  volume={73},
  pages={294 - 300}
}
Amplification of the CCDN1 gene encoding cyclin D1 was examined by Southern blotting and multiplex polymerase chain reaction (PCR) and occurred in 8 of 53 patients (15%) with primary resected non-small-cell lung cancer (NSCLC). These tumours and 17 additional tumours with a normal gene copy number showed overexpression of cyclin D1 (25/53, 47%), as assessed by immunostaining using a monoclonal antibody. In 22/25 cases, cyclin D1 was localised in the cytoplasm, but some (7/25) had simultaneous… CONTINUE READING
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