Prognostic significance of Bcl-xL in human hepatocellular carcinoma.

  title={Prognostic significance of Bcl-xL in human hepatocellular carcinoma.},
  author={Jota Watanabe and Fumiki Kushihata and Kazuo Honda and Atsuro Sugita and Norihiko Tateishi and Katsumi Mominoki and Seiji Matsuda and Nobuaki Kobayashi},
  volume={135 6},
BACKGROUND Proliferation and apoptosis of liver cancer cells are closely related phenomena. We investigated the correlation between overexpression of Bcl-xL, an anti-apoptosis-related protein of the Bcl-2 family, and the clinical course of hepatocellular carcinoma (HCC). METHODS Specimens from 7 HCC patients were used for Western blotting and immunoelectron microscopy tests. Samples from 33 HCC patients who had undergone hepatectomies were used for immunohistochemical staining. The degrees of… CONTINUE READING