Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer

@inproceedings{Baba2010PrognosticSO,
  title={Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer},
  author={Yoshifumi Baba and Katsuhiko Nosho and Kentaro Shima and Jeffrey A. Meyerhardt and Andrew T. Chan and Jeffrey A. Engelman and Lewis C. Cantley and Massimo F. Loda and Edward L. Giovannucci and Charles S. Fuchs and Shuji Ogino},
  booktitle={British Journal of Cancer},
  year={2010}
}
Background:AMP-activated protein kinase (AMPK, PRKA) has central roles in cellular metabolic sensing and energy balance homeostasis, and interacts with various pathways (e.g., TP53 (p53), FASN, MTOR and MAPK3/1 (ERK)). AMP-activated protein kinase activation is cytotoxic to cancer cells, supporting AMPK as a tumour suppressor and a potential therapeutic target. However, no study has examined its prognostic role in colorectal cancers.Methods:Among 718 colon and rectal cancers, phosphorylated… CONTINUE READING
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