Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma

@article{Qian2014PrognosticSO,
  title={Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma},
  author={Xu Qian and Steffen Wagner and Chenming Ma and Annekatrin Coordes and Julia Gekeler and Jens Klu\ssmann and Michael Hummel and Andreas M Kaufmann and Andreas E Albers},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2014},
  volume={140},
  pages={1151-1158}
}
Aldehyde dehydrogenase 1 (ALDH1A1) has now been recognized as a cancer stem(-like) cells (CSCs) marker in various tumors including head and neck squamous cell carcinoma (HNSCC). The objective of this study was to examine the expression of ALDH1A1 in patients with locally advanced, metastasized HNSCC and to determine its prognostic value. Human papillomavirus genotypes and expression of ALDH1A1, Twist1, and p16 were analyzed in specimens of 81 patients with primary HNSCC and 49 lymph node… CONTINUE READING