Prognostic significance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers.

@article{Ogino2009PrognosticSA,
  title={Prognostic significance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers.},
  author={Shuji Ogino and Katsuhiko Nosho and Natsumi Irahara and Kaori Shima and Yoshifumi Baba and Gregory J. Kirkner and Jeffrey A. Meyerhardt and Charles S. Fuchs},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 27},
  pages={4591-8}
}
PURPOSE Loss of heterozygosity (LOH) at chromosome 18q frequently occurs late during colon cancer development and is inversely associated with microsatellite instability (MSI). 18q LOH has been reported to predict shorter survival in patients with colorectal cancer, whereas MSI-high status has been associated with superior prognosis. However, it is unclear whether 18q LOH in colorectal cancer has any prognostic implication independent of MSI status and other potential predictors of clinical… CONTINUE READING

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