Prognostic significance and mechanism of Treg infiltration in human brain tumors.

@article{Jacobs2010PrognosticSA,
  title={Prognostic significance and mechanism of Treg infiltration in human brain tumors.},
  author={Joannes F M Jacobs and Albert J. Idema and Kalijn F. Bol and J Andre Grotenhuis and I Jolanda M de Vries and Pieter Wesseling and Gosse J Adema},
  journal={Journal of neuroimmunology},
  year={2010},
  volume={225 1-2},
  pages={195-9}
}
Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune responses observed in these tumors. We reported that the percentage of tumor infiltrating Tregs is strongly correlated with the WHO grade of the brain tumor. We now report on the clinical follow-up of this patient cohort (n=83). Subgroup analyses in patients with glioblastomas (n=29) showed a moderate, not significant, inverted association between Tregs and survival. We further show that Tregs in… CONTINUE READING

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