Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

@article{Cheng2015PrognosticSM,
  title={Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment},
  author={Lijun Cheng and James D Doecke and Robyn A. Sharples and Victor Villemagne and Christopher J Fowler and Alan R Rembach and Ralph N. Martins and Christopher C. Rowe and Stuart Lance Macaulay and Colin L. Masters and Andrew F. Hill},
  journal={Molecular Psychiatry},
  year={2015},
  volume={20},
  pages={1188-1196}
}
There is no consensus for a blood-based test for the early diagnosis of Alzheimer’s disease (AD). Expression profiling of small non-coding RNA’s, microRNA (miRNA), has revealed diagnostic potential in human diseases. Circulating miRNA are found in small vesicles known as exosomes within biological fluids such as human serum. The aim of this work was to determine a set of differential exosomal miRNA biomarkers between healthy and AD patients, which may aid in diagnosis. Using next-generation… CONTINUE READING
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