Prognostic role of methylated free circulating DNA in colorectal cancer.

  title={Prognostic role of methylated free circulating DNA in colorectal cancer.},
  author={Alexander Philipp and Petra Stieber and Dorothea Nagel and Jens Neumann and Fritz Spelsberg and Andreas Jung and Rolf M Lamerz and Andreas Herbst and Frank Thomas Kolligs},
  journal={International journal of cancer},
  volume={131 10},
DNA hypermethylation is frequently found in colorectal cancer (CRC). Methylation of helicase-like transcription factor (HLTF) and hyperplastic polyposis 1 (HPP1) are potential and carcinoembryonic antigen (CEA) is an established prognostic factor in serum of patients with CRC. The aim of this study was to perform a direct comparison of the prognostic roles of these markers. Methylation status of HLTF and HPP1 was examined in pretherapeutic sera of 311 patients with CRC and matched primary… CONTINUE READING
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