Prognostic role of circulating exosomal miRNAs in multiple myeloma.

  title={Prognostic role of circulating exosomal miRNAs in multiple myeloma.},
  author={Salomon Manier and Chia-Jen Liu and Herv{\'e} Avet-Loiseau and Jihye Park and Jiantao Shi and Federico Campigotto and Karma Z Salem and Daisy Huynh and Siobhan V Glavey and Bradley Rivotto and Antonio Sacco and Aldo M Roccaro and Juliette M Bouyssou and St{\'e}phane Minvielle and Philippe Moreau and Thierry Facon and Xavier Leleu and Edie Weller and Lorenzo Trippa and Irene M Ghobrial},
  volume={129 17},
Exosomes, secreted by several cell types, including cancer cells, can be isolated from the peripheral blood and have been shown to be powerful markers of disease progression in cancer. In this study, we examined the prognostic significance of circulating exosomal microRNAs (miRNAs) in multiple myeloma (MM). A cohort of 156 patients with newly diagnosed MM, uniformly treated and followed, was studied. Circulating exosomal miRNAs were isolated and used to perform a small RNA sequencing analysis… CONTINUE READING
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