Prognostic role of HuR in hereditary breast cancer.

@article{Heinonen2007PrognosticRO,
  title={Prognostic role of HuR in hereditary breast cancer.},
  author={Mira Heinonen and Rainer Fagerholm and Kirsimari Aaltonen and Outi Kilpivaara and Kristiina Aittom{\"a}ki and Carl Blomqvist and P{\"a}ivi Heikkil{\"a} and Caj Haglund and Heli Nevanlinna and Ari Ristim{\"a}ki},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 23},
  pages={6959-63}
}
PURPOSE HuR is an mRNA-binding protein that enhances the stability of certain transcripts and can regulate their translation. Elevated cytoplasmic expression of HuR protein has been linked to carcinogenesis and is associated with reduced survival in breast, ovarian, and gastric adenocarcinomas. EXPERIMENTAL DESIGN Here, we have explored the relevance of HuR in familial breast cancer. Tumor samples were collected from patients with identified BRCA1 (n = 51) or BRCA2 (n = 47) mutations or… CONTINUE READING
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