Prognostic role of HuR in hereditary breast cancer.

  title={Prognostic role of HuR in hereditary breast cancer.},
  author={Mira Heinonen and Rainer Fagerholm and Kirsimari Aaltonen and Outi Kilpivaara and Kristiina Aittom{\"a}ki and Carl Blomqvist and P{\"a}ivi Heikkil{\"a} and Caj Haglund and Heli Nevanlinna and Ari Ristim{\"a}ki},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 23},
PURPOSE HuR is an mRNA-binding protein that enhances the stability of certain transcripts and can regulate their translation. Elevated cytoplasmic expression of HuR protein has been linked to carcinogenesis and is associated with reduced survival in breast, ovarian, and gastric adenocarcinomas. EXPERIMENTAL DESIGN Here, we have explored the relevance of HuR in familial breast cancer. Tumor samples were collected from patients with identified BRCA1 (n = 51) or BRCA2 (n = 47) mutations or… CONTINUE READING
45 Citations
35 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 45 extracted citations


Publications referenced by this paper.
Showing 1-10 of 35 references

Expres - sion of the ELAVlike protein HuR in human colon cancer : Association with tumor stage and cyclooxygenase2

  • C Denkert, I Koch, N vonKeyserlingk
  • Mod Pathol
  • 2006

Cytoplas - mic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase2 expression in mucinous ovarian carcinoma

  • ErkinheimoTL, A Sivula, H Lassus
  • Gynecol Oncol
  • 2005

BRCA 1 and BRCA 2 : 1994 and beyond

  • SA Narod, FoulkesWD.
  • Nat Rev Cancer
  • 2004

Expression of the ELAVlike protein HuR is associatedwithhigher tumor grade and increased cyclooxygenase2 expression in human breast carcinoma

  • WeichertW Denkert C, KJ Winzer
  • Clin Cancer Res
  • 2004

Identification of a target RNA motif for RNA - binding protein HuR

  • I LopezdeSilanes, M Zhan, A Lal, X Yang, M Gorospe
  • Proc Natl Acad Sci U S A
  • 2004

Similar Papers

Loading similar papers…