Prognostic relevance of ubiquitin C-terminal hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients

@article{Schroeder2013PrognosticRO,
  title={Prognostic relevance of ubiquitin C-terminal hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients},
  author={Christine Schroeder and Karin Milde-Langosch and Florian Gebauer and Katharina Schmid and Volkmar Mueller and Ralph Markus Wirtz and Catherine Meyer-Schwesinger and Hartmut Schl{\"u}ter and Guido Sauter and Udo Schumacher},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2013},
  volume={139},
  pages={1745-1755}
}
The ubiquitin C-terminal hydrolase L1 (UCH-L1) belongs to the family of deubiquitinating enzymes. It is overexpressed in various tumour entities and associated with metastases formation in some solid tumours. However, only limited information about its role in breast cancer is available. The aim of this study was to examine the UCH-L1 expression in primary breast cancer and to determine its relevance as a potential prognostic marker. We investigated both UCH-L1 mRNA expression in microarray… CONTINUE READING

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