Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes: relationship to development of acute myeloid leukaemia

  title={Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes: relationship to development of acute myeloid leukaemia},
  author={Pellegrino Musto and Carlo Bodenizza and Antonietta Pia Falcone and Giovanni D’Arena and P R Scalzulli and Gianni Perla and Sergio Modoni and L Parlatore and Maria Rosa Valvano and Mario Carotenuto},
  journal={British Journal of Haematology},
The aim of this study was to evaluate the possible prognostic relevance of thymidine kinase serum levels (s‐TK), an indirect marker of proliferative activity, in myelodysplastic syndromes (MDS). S‐TK levels were monitored by means of a radioenzyme assay in 90 patients affected by MDS (22 refractory anaemia, RA; 17 RA with ring sideroblasts, RARS; 21 RA with blast excess, RAEB; 15 RAEB in transformation, RAEB‐T; 15 chronic myelomono‐cytic leukaemia, CMMoL). Mean s‐TK levels (U//tl) measured at… 

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This score was able to identify those patients with RA and RARS who, without showing an excess of marrow blasts, have an unfavorable prognosis, and a simple scoring system was devised for predicting the survival of patients with MDS.

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A staging system of immediate clinical utility for prognostic stratification and risk‐adapted therapeutic choices is devised and four objective parameters of proven significance (age, Hb, platelets, and BM blasts) are devised.

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Prognostic implications of bone marrow culturing in myelodysplastic syndrome: a retrospective analysis.

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