Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes: relationship to development of acute myeloid leukaemia

@article{Musto1995PrognosticRO,
  title={Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes: relationship to development of acute myeloid leukaemia},
  author={Pellegrino Musto and Carlo Bodenizza and Antonietta Pia Falcone and Giovanni D’Arena and P R Scalzulli and Gianni Perla and Sergio Modoni and L Parlatore and Maria Rosa Valvano and Mario Carotenuto},
  journal={British Journal of Haematology},
  year={1995},
  volume={90}
}
The aim of this study was to evaluate the possible prognostic relevance of thymidine kinase serum levels (s‐TK), an indirect marker of proliferative activity, in myelodysplastic syndromes (MDS). S‐TK levels were monitored by means of a radioenzyme assay in 90 patients affected by MDS (22 refractory anaemia, RA; 17 RA with ring sideroblasts, RARS; 21 RA with blast excess, RAEB; 15 RAEB in transformation, RAEB‐T; 15 chronic myelomono‐cytic leukaemia, CMMoL). Mean s‐TK levels (U//tl) measured at… 

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Summary. We have studied the clinical and laboratory features of 53 cases of chronic myelomonocytic leukaemia (CMML) defined according to the FAB criteria. A granulocyte count of < 16 x 109/l or a
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