Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes: relationship to development of acute myeloid leukaemia

  title={Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes: relationship to development of acute myeloid leukaemia},
  author={Pellegrino Musto and Carlo Bodenizza and Antonietta Pia Falcone and Giovanni D’Arena and P R Scalzulli and Gianni Perla and Sergio Modoni and L Parlatore and Maria Rosa Valvano and Mario Carotenuto},
  journal={British Journal of Haematology},
The aim of this study was to evaluate the possible prognostic relevance of thymidine kinase serum levels (s‐TK), an indirect marker of proliferative activity, in myelodysplastic syndromes (MDS). S‐TK levels were monitored by means of a radioenzyme assay in 90 patients affected by MDS (22 refractory anaemia, RA; 17 RA with ring sideroblasts, RARS; 21 RA with blast excess, RAEB; 15 RAEB in transformation, RAEB‐T; 15 chronic myelomono‐cytic leukaemia, CMMoL). Mean s‐TK levels (U//tl) measured at… 

Evaluating the prognosis of patients with myelodysplastic syndromes

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Changes of serum thymidine kinase in children with acute leukemia.

The study showed that the elevation of TK serum levels during follow-up was a helpful marker for the recognition of an early stage of relapse and in some cases occurred as early as one month before the appearance of clinical signs.

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The Bournemouth score for CMML proved to be a valid tool for predicting survival but not acute transformation, and underlines the coexistence of aspects typical of myelodysplastic and myeloproliferative syndromes.

Configuration of the TP53 Gene as an Independent Prognostic Parameter of Myelodysplastic Syndrome

Potential improvement of the IPSS by the addition of molecular analysis to the system is discussed, with particular reference to the configuration of the TP53 gene.

Elevated serum thymidine kinase activity in canine splenic hemangiosarcoma*.

Serum TK1 evaluation may help to discriminate between benign disease and HSA in dogs with hemoabdomen and a splenic mass in this prospective study.

Myelodysplastic syndromes. Contemporary biologic concepts and emerging diagnostic approaches.

It is anticipated that a more rational and objective approach to the diagnosis and classification of MDS may be achieved, affording the use of more effective targeted therapy.

The Clinical Significance of Thymidine Kinase 1 Measurement in Serum of Breast Cancer Patients Using Anti-TK1 Antibody

In conclusion, the anti-TK1 antibody could be a good marker for monitoring the response of breast cancer patients to therapy.

Diagnostic implications of the molecular forms and levels of serum thymidine kinase 1 in different canine malignancies

Overall, the results demonstrate that TK1 protein assays provide valuable diagnostic information in a variety of canine malignancies.

Thymidine kinase assay in canine lymphoma.

TK levels were not higher in dogs with higher stage disease and TK activity prior to treatment was not associated with DFR or survival, and where TK was elevated at diagnosis, it fell into the reference range during remission.

Comparison of diagnostic and prognostic performance of two assays measuring thymidine kinase 1 activity in serum of breast cancer patients

Two recently developed immunoassays for serum thymidine kinase 1 (TK1) activity, DiviTum and Liaison, may be used for recurrence prediction in preoperative evaluation of BC patients.



Primary myelodysplastic syndromes: analysis of prognostic factors in 235 patients and proposals for an improved scoring system.

This score was able to identify those patients with RA and RARS who, without showing an excess of marrow blasts, have an unfavorable prognosis, and a simple scoring system was devised for predicting the survival of patients with MDS.

Risk assessment in myelodysplastic syndromes: Value of clinical, hematologic and bone marrow histologic findings at presentation

A staging system of immediate clinical utility for prognostic stratification and risk‐adapted therapeutic choices is devised and four objective parameters of proven significance (age, Hb, platelets, and BM blasts) are devised.

Myelodysplastic syndromes: a multiparametric study of prognostic factors and a proposed scoring system.

In 72 consecutive patients with previously untreated myelodysplastic syndromes (MDS), a multiple regression analysis was conducted of the prognosis significance of 26 clinical and laboratory parameters, including bone marrow (BM) biopsy characteristics, to construct a scoring system for survival prediction.

Prognostic implications of bone marrow culturing in myelodysplastic syndrome: a retrospective analysis.

In vitro bone marrow culturing has predictive value for AML development in RA(RS) patients and patients with normal growth and differentiation withnormal growth predict a better survival, while in RAEB(t), the predictive value is less pronounced.

Proposals for the classification of the myelodysplastic syndromes

It is now proposed that over 30% of bone marrow blasts will suffice for the diagnosis of acute myeloid leukaemia (AML) in any of its forms (M1‐M6) and recognition of the new category, RAEB in transformation, may throw light on the pathogenesis of AML.

Mechanisms and prognostic value of cell kinetics in the myelodysplastic syndromes

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Serum thymidine kinase in monoclonal gammopathies. A prospective study

It is indicated that TK has clinical and prognostic relevance in monoclonal gammopathies, and additional investigations are warranted to determine whether it is a useful tool for the clinical evaluation, staging, and follow‐up of patients with MM.

CD34 immunohistochemistry of bone marrow biopsies: Prognostic significance in primary myelodysplastic syndromes

CD34 immunostaining, which can be easily performed on routinely prepared BM biopsies, was found to be a powerful prognostic tool for predicting survival and outcome in MDS.

Bone marrow histology in myelodysplastic syndromes

It is concluded that bone marrow biopsy provides useful information for the prognosis of MDS and that the presence of ALIP has greater predictive value than the more commonly used parameters deduced from cytology and karyotype.