Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer.

@article{Ganesh1994PrognosticRO,
  title={Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer.},
  author={Shashikiran Ganesh and Cornelis Fm Sier and Gerrit Griffioen and H. J. Vloedgraven and Annemiek J. de Boer and K. Welvaart and Cornelius J H van de Velde and Johan Hjm van Krieken and Jan H. Verheijen and Cornelis B. H. W. Lamers},
  journal={Cancer research},
  year={1994},
  volume={54 15},
  pages={4065-71}
}
Human colorectal carcinogenesis has been shown previously to be associated with impressive changes in the tissue levels of plasminogen activators and their inhibitors, exemplified by an increase in the urokinase-type plasminogen activator (u-PA) and the inhibitors PAI-1 and PAI-2, and a decrease in tissue-type plasminogen activator (t-PA). In the present study we evaluated the prognostic significance of these parameters to the overall survival of patients with colorectal cancer, in conjunction… CONTINUE READING

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