Prognostic relevance of TGF-beta1 and PAI-1 in cervical cancer.

  title={Prognostic relevance of TGF-beta1 and PAI-1 in cervical cancer.},
  author={Suzanne Hazelbag and Gemma G Kenter and Arko Gorter and Gert Jan J Fleuren},
  journal={International journal of cancer},
  volume={112 6},
Cervical carcinoma is a human papilloma virus (HPV)-related immunogenic type of malignancy, in which escape of the tumor from the hosts' immune response is thought to play an important role in carcinogenesis. The multifunctional cytokine transforming growth factor-beta(1) (TGF-beta(1)) is involved in immunosuppression, stroma and extracellular matrix formation and controlling (epithelial) cell growth. The plasminogen activating (PA) system plays a key role in the cascade of tumor-associated… CONTINUE READING