Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer

@article{Nakanishi2012PrognosticRO,
  title={Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer},
  author={Ryota Nakanishi and Jun Harada and Munkhbold Tuul and Yan Zhao and Koji Ando and Hiroshi Saeki and Eiji Oki and Takefumi Ohga and Hiroyuki Kitao and Yoshihiro Kakeji and Yoshihiko Maehara},
  journal={International Journal of Clinical Oncology},
  year={2012},
  volume={18},
  pages={1042-1048}
}
Mutations of the KRAS or BRAF genes are now recognized as prognostic markers for colorectal cancer (CRC). They are also important predictive markers for resistance to the monoclonal antibodies that target the epidermal growth factor receptor. In this retrospective study, KRAS and BRAF mutations were analyzed using a direct sequence method in 254 Japanese CRC patients, and the associations between KRAS or BRAF mutations and clinicopathological characteristics or outcome were evaluated. KRAS and… CONTINUE READING