Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials.

@article{Tran2012PrognosticOP,
  title={Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials.},
  author={Hai T. Tran and Yuan Liu and Amado J. Zurita and Ying Lin and Katherine L Baker-Neblett and A M Martin and Robert Alan Figlin and Thomas E. Hutson and Cora N Sternberg and Rafael G. Amado and Lini N. Pandite and John V. Heymach},
  journal={The Lancet. Oncology},
  year={2012},
  volume={13 8},
  pages={827-37}
}
BACKGROUND Several targeted drugs are approved for treatment of patients with metastatic renal-cell cancer, but no validated biomarkers are available for prediction of clinical outcome. We aimed to assess the prognostic and predictive associations of pretreatment plasma concentrations of cytokine and angiogenic factors (CAFs) with data from a phase 2 and a phase 3 trial of pazopanib treatment. METHODS We used a three-step approach for screening, confirmation, and validation of prospective CAF… CONTINUE READING
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