Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.

@article{Neubauer1994PrognosticIO,
  title={Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.},
  author={Andreas Neubauer and Richard K. Dodge and Stephen L. George and Frederick R. Davey and Richard T. Silver and Charles A Schiffer and Robert J. Mayer and Edward D. Ball and Doris H. Wurster-Hill and Clara D. Bloomfield},
  journal={Blood},
  year={1994},
  volume={83 6},
  pages={1603-11}
}
Mutations of the N- and K-ras genes are the most frequent genetic aberrations in acute myeloid leukemia (AML) and their detection in preleukemic conditions such as the myelodysplastic syndrome (MDS) suggests a role in the earliest phases of leukemogenesis. Despite these observations, little is known about the clinical importance of ras mutations in AML. We… CONTINUE READING