Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia

@article{Neubauer1994PrognosticIO,
  title={Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia},
  author={Andreas Neubauer and Richard K. Dodge and Stephen L. George and Frederick R. Davey and Richard T. Silver and Celia A. Schiffer and Robert J. Mayer and Edward D. Ball and Doris H. Wurster-Hill and Clara Derber Bloomfield},
  journal={Blood},
  year={1994},
  volume={83},
  pages={1603-1611}
}
Mutations of the N- and K-ras genes are the most frequent genetic aberrations in acute myeloid leukemia (AML) and their detection in preleukemic conditions such as the myelodysplastic syndrome (MDS) suggests a role in the earliest phases of leukemogenesis. Despite these observations, little is known about the clinical importance of ras mutations in AML. We studied the clinical impact of ras mutations in 99 patients with de novo AML. All patients were treated in two prospective multicenter… 
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TLDR
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TLDR
The FLT3 gene mutation, whose presence is detectable only by genomic polymerase chain reaction amplification and gel electrophoresis, might serve as an important molecular marker to predict the prognosis of patients with AML.
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia.
TLDR
The FLT3 gene mutation, whose presence is detectable only by genomic polymerase chain reaction amplification and gel electrophoresis, might serve as an important molecular marker to predict the prognosis of patients with AML.
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TLDR
The overall survival and AML-free survival were significantly shorter in patients with N-ras mutations than in those without these abnormalities, and the possible correlation between the presence of the mutation and clinical features was evaluated.
RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group
TLDR
The occurrence of clinical events at relatively late period should be monitored for in AML patients with mutations in RAS, as the presence of RAS mutation was related to late relapse.
FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.
TLDR
Results indicate that mutations in FLT3, RAS, or TP53 are common in older patients with AML and are associated with specific AML phenotypes as defined by laboratory values, cytogenetics, and clinical outcomes.
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