Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure*

@article{Schmidt2006PrognosticIO,
  title={Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure*},
  author={Lars Ebbe Schmidt and Fin Stolze Larsen},
  journal={Critical Care Medicine},
  year={2006},
  volume={34},
  pages={337-343}
}
Objective:Hyperlactatemia has been suggested as a prognostic marker in acetaminophen-induced fulminant hepatic failure, and a modification of the King’s College Hospital criteria to incorporate arterial lactate measurements has recently been proposed. The aims of the present study were to further evaluate arterial lactate as a prognostic marker in acetaminophen-induced fulminant hepatic failure and to analyze its relationship to known causes of hyperlactatemia such as multiple organ failure and… 
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References

SHOWING 1-10 OF 33 REFERENCES
Earlier identification of patients at risk from acetaminophen-induced acute liver failure.
TLDR
The crude admission APACHE II score correlated well with mortality in patients with acetaminophen-induced acute liver failure, however, the calculated APAChe II risk of death, using the original drug overdose coefficient, was poorly calibrated.
Blood lactate as a prognostic marker in acetaminophen‐induced acute liver failure
TLDR
Arterial blood lactate measurement rapidly and accurately identifies patients who will die from paracetamol‐induced acute liver failure and could improve the speed and accuracy of selection of appropriate candidates for transplantation.
Infection and the progression of hepatic encephalopathy in acute liver failure.
Acute liver failure: Clinical features, outcome analysis, and applicability of prognostic criteria
TLDR
It is concluded that early prognostication is needed in patients with ALF to assist decision making regarding OLT and the fulfillment of KCH criteria usually predicts a poor outcome, but a lack of fulfillment does not predict survival.
Serum phosphate is an early predictor of outcome in severe acetaminophen‐induced hepatotoxicity
TLDR
It is proposed that hyperphosphatemia after acetaminophen overdose is caused by renal dysfunction in the absence of hepatic regeneration, as the latter appears to be associated with lowering of serum phosphate.
...
...